‘Yes, that is definitely about correct. I seek out a Bodily understanding of biological devices inside a base-up way. I do think you can distinguish 3 strains of study in my group for the time being. The 1st concerns chromosome construction: How would you receive a metre-extended DNA polymer folded and organised in this kind of microscopic mobile? We have produced visualisation tactics that allow for us to study how, as an example, SMC proteins loop DNA (movie on Youtube) so that you can build up chromosomes.
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Multicolor imaging from the bacterial nucleoid and cell division proteins with blue, orange, and near-infrared fluorescent proteins
Our get the job done was immediately adopted up by others, most notably by Phaedon Avouris and colleagues at IBM, who in Oct 1998 posted their conclusions on transistors made from one- and multi-walled carbon nanotubes in Used Physics Letters.
This yielded a breakthrough. In just just a few months, we were in the position to measure transportation via someone single-walled carbon nanotube. Based upon reduced-temperature experiments by an excellent PhD student in my team, Sander Tans (now a valued colleague and professor at Delft College of Technological innovation with an Energetic research lab at AMOLF in Amsterdam), we showed that carbon nanotubes were being real quantum wires with pretty lengthy (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic conduct.
From the yrs adhering to these discoveries, my analysis interests shifted to biophysics and nanobiology, And that i turned considerably less involved with the development of nanotube electronics. The focus of numerous scientists in the field also shifted to graphene (where, funnily more than enough, the main graphene ribbons ended up described as ‘nanotubes that are Slash open up along their duration’) immediately after the discovery of The 2-dimensional content in 2004.
You're a Christian. If you may make this kind of synthetic mobile, would you be just one phase nearer to God, or would the position of God have diminished relatively all over again?
Instance (one) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is revealed in grey, the rim of the pore is highlighted in pink, as well as a 3D rendering of your motion of the DNA rod is shown.
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Dekker started out his study on one carbon nanotubes in 1993 when he put in place a fresh line of research to review electrical transport as a result of solitary organic molecules concerning nanoelectrodes. In 1996 a breakthrough was recognized with carbon nanotubes. This was accomplished in a collaboration with the team of Nobel laureate Richard Smalley. STM and nanolithography methods were being accustomed to demonstrate that these nanotubes are quantum wires at The only-molecule level, with remarkable physical Houses.
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Strong-state nanopores have verified for being a astonishingly adaptable probe for solitary-molecule Investigation of DNA. I'll describe a number of our latest results – exclusively DNA knots – and also our initiatives to increase the capabilities of strong-state nanopores even further, in the direction of one-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.